亚洲国产午夜精品理论片在线播放,人妻无码中文字幕,八戒看免费高清电视剧大全,国产精品久久久一区二区三区

加入收藏 | 設(shè)為首頁 | 聯(lián)系我們

產(chǎn)品搜索

聯(lián)系我們

聯(lián)系人：蔣經(jīng)理
電話：4008750250
號碼：
手機：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com

產(chǎn)品展示 / PRODUCTS
藥靶細胞株 > kinase激酶細胞株 > CBP73194ETV6-NTRK3/BaF3

ETV6-NTRK3/BaF3
名稱 ETV6-NTRK3/BaF3
型號 CBP73194
報價
特點 ETV6-NTRK3/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細內(nèi)容


CBP73194

I. Introduction

Cell Line Name：

ETV6-NTRK3/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS+1 ug/ml puromycin

Mycoplasma Status:

Negative


II.Background
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the NTRK3 gene located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q25.3) to create the (12;15)(p13;q25) fusion gene, ETV6-NTRK3. This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. ETV6-NTRK3 therefore codes for an chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the ETV6 protein fused to the tyrosine kinase (i.e. PTK) domain of the NTRK3 protein. The ETV6 gene codes for the transcription factor protein, ETV6, which suppresses the expression of, and thereby regulates, various genes that in mice are required for normal hematopoiesis as well as the development and maintenance of the vascular network. NTRK3 codes for Tropomyosin receptor kinase C a NT-3 growth factor receptor cell surface protein that when bound to its growth factor ligand, neurotrophin-3, becomes an active tyrosine kinase that phosphorylates tyrosine residues on, and thereby stimulates, signaling proteins that promote the growth, survival, and proliferation of their parent cells. The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phophorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation-induced papillary thyroid carcinoma.

III. Representative Data

1. WB of  ETV6-NTRK3/BaF3 expression

CBP73194 WB.jpg

2. Anti-proliferation assay

CBP73194 fig.png

Figure 2. Anti-proliferation assay of two reference compounds on the ETV6-NTRK3/BaF3 Stable Cell Line



如果你對CBP73194ETV6-NTRK3/BaF3感興趣，想了解更詳細的產(chǎn)品信息，填寫下表直接與廠家聯(lián)系：


留言框

  • 產(chǎn)品：

  • 您的單位：

  • 您的姓名：

  • 聯(lián)系電話：

  • 常用郵箱：

  • 省份：

  • 詳細地址：

  • 補充說明：

  • 驗證碼：

    請輸入計算結(jié)果（填寫阿拉伯數(shù)字），如：三加四=7

化工儀器網(wǎng)

推薦收藏該企業(yè)網(wǎng)站
最新国产福利片在线观看| 日韩精品中文字幕在线观| www视频在线观看视频| 美女张开腿让人桶| 亚洲aaa视频| 女人十八片毛片免费视频| 九九九九九九九九国产精品| 99re视频在线免费看| 征服丰满人妻老师| 少妇口述炮约真实经历| 亚洲A片成人片在线观看| 人人爱天天做夜夜爽毛片| 亚洲精品无码乱码成人| av免费看无码| 日本人妻电影中文一区二区| 亚洲国产成人久久笫一页| 男男扒开伸进| 在线免费观看的av电影| 精品人妻少妇嫩草av无码专区| 亚洲综合熟女久久久30p| 2021精品人妻少妇网站| 91精品影视作品在线观看| 日韩精品一区二区三区乱码| 欧美金发尤物av在线观看| 国产免费阿v精品视频网址| 黑人巨茎大战白人美女| 日本男人操女人| 影音先锋中文字幕人妻| 99re在线精品免费观看| 超碰国产精品久久国产精品99| 娇妻系列交换纯肉高h| 亚洲日韩欧洲乱码av夜夜摸| 91日韩电影| 亚洲 激情 欧美 久久| 公玩弄年轻人妻hd| 2023久久久| 淫神猎艳录小说| 一本到在线观看视频不卡| 欧美一区二区成人在线观看| chinese 真实露脸自拍| 欧美一区二区三区啪啪|